- Author
-
Hartzell, G. E.
|
Packham, S. C.
|
Switzer, W. G.
- Title
- Toxic Hazards of Smoke.
- Coporate
- Southwest Research Inst., San Antonio, TX
- Book or Conf
- International Conference on Flammability. INTERFLAM '85. Conference Workbook. March 26-28, 1985,
Guildford, England,
84-107 p.,
1985
- Keywords
-
toxic hazards
- Abstract
- Research in combustion toxicology over the past few years has led to a reasonable understanding and even quantification of some of the effects of fire effluent toxicants and, with the availability of a modest amount of both non-human primate and human exposure data, the combustion toxicologist is gaining increasing capability to assess and predict the toxicological effects of smoke inhalation. This paper presents an introductory overview of the toxicology of fire effluents, with attention to the relevance of laboratory animal data to possible effects on humans. Following the overview, an elementary mathematical model is described which has been successful for predicting single-toxicant effects on laboratory animals. The concepts described may ultimately obviate routine use of such animals for combustion toxicity testing and also open the way to the prediction of toxicological effects on humans exposed to fires.