- Author
- Murphy, J. P. F. | Van Stee, E. W. | Back, K. C.
- Title
- Effect of Dibromotetrafluoroethane Inhalation on Hepatic Drug Metabolism in Mice.
- Coporate
- Air Force Systems Command, Wright-Patterson AFB, OH
- Journal
- Biochemical Pharmacology, Vol. 22, 2843-2851, 1973
- Report
- AMRL-TR-72-109,
- Distribution
- Available from National Technical Information Service
- Keywords
- inhalation | animals
- Abstract
- Inhalation of dibromotetrafluoroethane, 0-63 to 1-0% for 5 hr. daily for 3 or 4 days, reduced hexobarbital sleeping time and zoxazolamine paralysis time 2-fold in mice. Increased metabolism of hexobarbital and zoxazolamine by the tepatic 9000 g microsomal supernatant fraction prepared from exposed mice correlated well with the effects determined in vivo. Addition of 2,4-dichloro-6-phenyl-pheroxyethyldiethylamine (SKF 525-A) to the hepatic 9000 g microsomal supernatant fraction prevented the dibrtomotetrafluoroethane-induced increase in hepatic drug metabolism.