- Author
-
Vinegar, A.
|
Jepson, G. W.
|
Rubenstein, R.
|
Brock, W. J.
- Title
- Setting Safe Acute Exposure Limits for Halon Replacement Chemicals Using Physiologically Based Pharmacokinetic Modeling.
- Coporate
- Man Tech Environmental Technology, Wright-Patterson AFB, OH
Great Lakes Chemical Corp., West Lafeyette, IN
Environmental Protection Agency, Washington, DC
DuPont Company, Newark, DE
- Journal
-
Insulation Toxicology,
Vol. 12,
No. 8,
751-763,
August 2000
- Keywords
-
halon alternatives
|
exposure
|
blood
|
human beings
|
cardiac effects
|
simulation
|
halon 1301
|
Monte Carlo method
- Identifiers
- Physiologically Based Pharmacokinetic (PBK) modeling; lowest-observed-adverse-effect level (LOAEL) for cardiac sensitization; target arterial concentrations of chemical in blood; chemical-specific model parameters and values