- Author
- Yamamoto, K.
- Title
- On the Acute Toxicities of the Combustion Products of Various Fibers, with Special Reference to Blood Cyanide and Po2 Values.
- Coporate
- Kyoto Univ., Japan
- Journal
- Zeitschrift fur Rechtsmediine, Vol. 81, 173-180, 1978
- Sponsor
- National Bureau of Standards, Gaithersburg, MD
- Report
- NBS SP 540
- Distribution
- Available from Government Printing Office
- Book or Conf
- National Bureau of Standards. Fire Research and Safety. 3rd Joint Panel proceedings Conference of the U.S. Japan Cooperative Program in Natural Resources (UJNR). March 13-17, 1978, National Bureau of Standards, Gaithersburg, MD, Sherald, M. A., Editors, 520-527 p., 1979
- Keywords
- combustion products | toxic gases
- Abstract
- The evaluation method of the toxicities of various materials at fires and the studies on the harmful effects of various combustion products are considered to be the main subjects in the toxicology on combustion. The present report chiefly concerns with the second item. Combustion toxicology generally deals with the gaseous form, therefore, inhalation route is the main entrance route of the toxicants into the bodies. There can be marked differences in concentrations and in distribution patterns of the toxic materials in the body with different routes of administration. That the above can hold for cyanide too was indicated in the author's previous experiments with rats and rabbits, in which two routes of administration, per os and inhalation routes, were used [1]. Since there is only a limited number of data on the distribution of cyanide in the body exposed to HCN gas [2,3,4,5,6], it seemed to be worthwhile, as a first step to obtain such basic data, to determine the blood cyanide concentrations in the different parts of the body. The present reort includes the data on blood Po2 level as well as cyanide. This is based on the following considerations that this parameter can be used for a diagnosis, whether death is an asphyxial one or not, and that Po2 can become a key to the problem of identity of the gases responsible for the toxic effects of the combustion products.