- Author
-
Coulston, F.
|
Griffin, T. B.
- Title
- Study of Toxicological Evaluation of Fire Suppressants and Extinguishers. Final Report.
- Coporate
- Albany Medical College, NY
- Sponsor
- National Aeronautics and Space Admin., Washington, DC
- Report
-
NASA-CR-147658,
March 31, 1975,
209 p.
- Distribution
- Available from National Technical Information Service
- Contract
- NAS9-9964
- Keywords
-
toxicology
|
fire extinguishers
|
evaluation
|
poisons
|
toxicity
|
hazards
|
closed ecological systems
|
exposure
|
fluorocarbons
|
respiration
- Identifiers
- fire extinguishing agents
- Abstract
- The application of fluorocarbons as possible candidates for fire extinguishers and/or suppressants in confined spaces (such as spacecraft, aircraft, or submarines) was investigated, with special emphasis on their safety to man since they would be inhaled on an almost continuous basis. Short-term exposure experiments, using various animal species, were devised to look at specific parameters in order to determine which of the candidate compounds were sufficiently non-toxic to warrant long-term investigations. The following physiologic criteria were examined: tissue distribtuion, fluoride concentration, effect on mitochondria, microsomes, liposomes, and liver cell nuclei, erythrocyte fragility, clinical chemistry values, hematology, pathology, cardiac sensitization, behavioral effects. Various rodent species were used for initial investigations, with non-human primate exposures for Freon 116 which was warranted for negative results on rodents.