- Author
-
Syracuse Research Corporation
- Title
- Information Profiles on Potential Occupational Hazards: Inorganic Azides. Second (2nd) Draft.
- Coporate
- Syracuse Research Corp., NY
- Sponsor
- National Institute for Occupational Safety and Health, Rockville, MD
- Report
-
SRC TR 81-608,
October 1981,
58 p.
- Distribution
- Available from National Technical Information Service
- Contract
- NIOSH-CONTRACT-210-79-0030
- Keywords
-
azides (organic)
|
irritants
|
nervous system
|
occupational hazards
|
human beings
|
exposure
|
animals
- Identifiers
- biological activity; barium azide; cesium azide; hydrazoic acid (hydrogen azide); lead azide; lithium azide; potassium azide; rubidium; rubidium azide; silver azide; sodium azide; mice; monkeys; organo metallic compounds; pesticides; agricultural chemicals; preservatives; occupational exposure; toxic effects; mutagens; brain damage
- Abstract
- Information was presented for the following inorganic azides: barium-azide (18810587); cesium-azide (22750578); hydrazoic-acid (7782798); lead-azide (13424469); lithium-azide (19597694); potassium-azide (20762601); rubidium-azide (22756361); silver-azide (13863882); and sodium-azide (26628228). The data given for each compound included chemical structure, synonyms, chemical and physical properties, production information, uses, manufacturers and distributors, manufacturing processes, impurities and additives, occupational exposures, control technology and work practices, biological effects, ongoing studies, exposure standards, and sources of additional information. While there did not appear to be a lot of research available on toxicity of inorganiz azides what findings there were suggested that toxic effects are due to the azoimide radical. The major acute effects of toxic doses of either sodium-azide or hydrazoic-acid to animals included hypotension, respiratory stimulation and convulsions, followed by respiratory depression and death. Humans who have suffered accidental exposures experienced inflammation of the mucous membranes and eye irritation. Necrosis and demyelination of nerve fibers were reported among mice and monkeys following acute intraperitoneal and subchronic intramuscular exposures, respectively. Subchronic oral exposure to rats caused histologic cerebral and liver damage. Mutagenicity testing was positive for sodium-azide in a variety of assays.