- Author
- Farrar, D. G. | Hiuleman, F. D. | Blank, T. L. | Pope, D. L.
- Title
- Study on the Sensitivity of the Leg-Flexion Avoidance Response to the Sensory Irritant Component of Douglas FIR Combustion Products, December 1979.
- Coporate
- Utah Univ., Salt Lake City
- Sponsor
- National Bureau of Standards, Gaithersburg, MD
- Report
- NBS GCR 82-381, March 1982, 56 p.
- Distribution
- Available from National Technical Information Service
- Contract
- UTEC79-143
- Keywords
- carbon monoxide | combustion products | experimental design | animals | thermal degradation | toxic gases | toxicity | wood
- Abstract
- Experiments which were conducted to determine the effect of experimental conditions on the sensitivity of the leg-flexion avoidance response of the rats to combustion products, particularly sensory irritants e.g., acrolein. The experiments showed that there were ill-defined relationships between the strength of the electrical stimulus given to rats to train them to perform the response, and the sensitivity of the response to environmental contaminants. The value of the leg-flexion avoidance response as a model for the detection of the potential incapacitation due to the presence of sensory irritants in the environment is discussed.