- Author
-
Strauch, S. M.
- Title
- Electrophysiologic Mechanisms of Halogenated Alkane Arrhthmogenesis. Final Report. July 1, 1979-August 31, 1982.
- Coporate
- Ohio State Univ., Columbus
- Sponsor
- Air Force Office of Scientific Research, Washington, DC
- Report
-
AFOSR-TR-83-0436,
March 1, 1983,
133 p.
- Distribution
- Available from National Technical Information Service
- Contract
- RF-PROJECT-761648-712005
- Keywords
-
alkanes
|
bromochlorodifluoromethane
|
cardiac effects
|
animals
|
experiments
- Identifiers
- dogs; cardiac electrophysiologic parameters; canine Purkinje action potential; cardiac arrhythmia; cardiac sensitization; adrenergic amines; cyclic adenosine monophosphate
- Abstract
- Bromochlorodifluoromethane (1211) has been shown to sensitize the myocardium to the arrhythmogenic effects of adrenergic amines. Various physiological and pharmacologic interventions were shown to modify both FC 1211 membrane effects as well as the FC 1211 sensitization process. These interventions included alternations in potassium concentration, applying stretch to Purkinje fibers, production of hypoxic conditions, alpha adrenergic effects and beta blockade of calcium mediated slow channel effects. In studies combining cyclic nucleotide measurements with electrophysiologic parameters, it was shown that isoproterenol and FC 1211 act in an additive way to increase cyclic adenosine monophosphate levles in Purkinje fibers. Effects of FC 1211 in conscious dogs indicated that the arrhythomgenic action is due to cardiac sensitization and mediated through beta receptors.