- Author
-
Hartzell, G. E.
|
Grand, A. F.
|
Kaplan, H. L.
- Title
- Analysis of Hazards to Life Safety in Fires: A Comprehensive Multi-Dimensional Research Program. Part 3. Final Report.
- Coporate
- Southwest Research Inst., San Antonio, TX
- Sponsor
- National Institute of Standards and Technology, Gaithersburg, MD
- Report
-
SWRI Project 01-1257
October 1988
27 p.
- Contract
- NIST-GRANT-60NANB6D0635
- Keywords
-
life safety
|
fire hazards
|
fire gases
|
carbon monoxide
|
hydrogen cyanides
|
carbon dioxide
|
hydrogen chloride
|
inhalation
|
animals
- Abstract
- In order for a fire hazard model to be valid, it is essential that results obtained in combustion toxicity studies on materials be predictive, with a reasonable degree of confidence, of the effects of smoke exposure to humans. Because of potentially significatnt differences between the mouse or rat and the primate, studies were undertaken to investigate the suitability of other rodent species and to develop methodology that could allow rodent dat to be used more effectively to predict toxic effects in humans. The specific objective of this work was to investigate the suitability of the guinea pig as a model for predicting the toxic effects of fire gases, particularly those containing irritants, in man.