- Author
- Stokinger, H. E.
- Title
- Suggested Principles and Procedures for Developing Experimental Animal Data for Threshold Limit Values for Air.
- Keywords
- air pollution | animals | exposure | LC-50 | inhalation | toxicity | experiments | acute toxicity | inhalation toxicity
- Identifiers
- duration - chronic study requirement; animal species requirement; multi-level exposure requirement; 'no effect level'; short-term limits; chemical identification of product; subacute inhalation toxicity studies; chronic toxicity studies
- Abstract
- The guidelines set forth in this paper are not to be constructed that the Threshold Limit Values Committee is interested only in information that meets the minimal standards outlined here. All new additional types of information relatint to TLVs, provided it is well documented, is welcomed. The Threshold Limit Values (TLVs) for air of occupational environments are, with certain exceptions, time-weighted average concentrations of chemical substances that apply to repeated, 8-hour exposures, 5 days weekly, throughout a worker's lifetime. Exceptions are the substances given in Appendix A and those given a "C" listing. A "C" listing refers to a 'ceiling' value that should not exceed, and thus is similar to the MAC. The substances to which a ceiling value applies, the basis for this choice, as well as other matters pertinent to the TLVs are given in the annual list of threshold limits.